I-FLT3

IKATI #	Igama Lomkhiqizo	Incazelo
I-CPDB0099	I-Quizartinib; I-AC-010220; I-AC-220	I-Quizartinib iyi-inhibitor ye-FMS ehlobene ne-tyrosine kinase 3 (FLT3; Kd = 1.6 nM) futhi ibonisa ukukhetha okuphezulu kwe-FLT3 uma ihlolwe ngokumelene nephaneli ye-227 kinases eyengeziwe. Ivimbela ukwanda komugqa womuntu we-leukemia cell MV4-11, ephethe ukuguqulwa kwe-homozygous FLT3-ITD, enenani le-IC50 elingu-0.56 nM.1 Ku-1 mg/kg/ngosuku, i-quizartinib ikhonjiswe ukuthi yandisa ukuphila egundwaneni. imodeli ye-FLT3-ITD acute myeloid leukemia kanye nokuqeda izimila kumodeli ye-xenograft yegundane elincike ku-FLT3 ngo-10 mg/kg.