| IKATI # | Igama Lomkhiqizo | Incazelo |
| I-CPD100464 | Erdafitinib | I-Erdafitinib, eyaziwa nangokuthi i-JNJ-42756493, iyi-bioavailable yomlomo enamandla futhi ekhethayo, i-pan fibroblast growth factor receptor (FGFR) inhibitor enomsebenzi ongaba khona we-antineoplastic. Ekuphathweni komlomo, i-JNJ-42756493 ibophezela futhi ivimbele i-FGFR, okungase kuphumele ekuvinjweni kwezindlela zokudluliselwa kwesignali ezihlobene ne-FGFR futhi ngaleyo ndlela kuvinjwe ukwanda kwamangqamuzana e-tumor nokufa kwe-tumor cell kumaseli e-tumor e-FGFR-overexpressing overexpressing. I-FGFR, elawulwa ezinhlotsheni eziningi zamaseli e-tumor, iyi-receptor tyrosine kinase ebalulekile ekwandeni kwamangqamuzana e-tumor, ukuhlukaniswa nokuphila. |
| I-CPD3618 | I-TAS-120 | I-TAS-120 iyi-oral bioavailable inhibitor ye-fibroblast growth factor receptor (FGFR) enekhono lomsebenzi we-antineoplastic. I-FGFR inhibitor TAS-120 ibophezela ngokukhetha futhi ngokungenakuhlehliswa kokuthi ivimbele i-FGFR, okungase kuphumele ekuvinjweni kokubili kwendlela yokudlulisela isignali ephakathi kwe-FGFR kanye nokwanda kwamaseli e-tumor, kanye nokwanda kokufa kwamaseli kumaseli e-FGFR-expressing overexpressing tumor. I-FGFR iyi-receptor tyrosine kinase ebalulekile ekwandeni kweseli yesimila, ukuhlukaniswa nokuphila futhi ukubonakaliswa kwayo kulawulwa ezinhlotsheni eziningi zamaseli wesimila. |
| Idatha ye-CPDB1093 | I-Derazantinib; I-ARQ-087 | I-Derazantinib, eyaziwa nangokuthi i-ARQ-087, iyisivimbeli esitholakala ngomlomo se-fibroblast growth factor receptor (FGFR) esinomsebenzi we-antineoplastic ongaba khona. |
| Idatha ye-CPDB0942 | I-BLU-554 | I-BLU-554 iyi-fibroblast growth factor receptor 4 (FGFR4) inhibitor engase ibe ukwelashwa kwe-hepatocellular carcinoma kanye ne-cholangiocarcinoma. |
| CPD0999 | I-H3B-6527 | I-H3B-6527 (H3 Biomedicine) iyisivimbeli se-FGFR4 esikhetha kakhulu esinomsebenzi onamandla we-antitumour kumigqa yeseli ekhulisiwe ye-FGF19 namagundane. |
| CPD0997 | FGF401 | I-FGF-401 iyi-inhibitor ye-FGFR4 ekhishwe ku-patent WO2015059668A1, isibonelo esiyinhlanganisela 83; ine-IC50 ye-1.9 nM. |
| Idatha ye-CPDB0053 | I-AZD4547 | I-AZD 4547 iyi-inhibitor ekhethiwe ye-fibroblast growth factor receptor (FGFR) i-tyrosine kinase enamanani e-IC50 angu-0.2, 2.5, kanye no-1.8 nM we-FGFR1, 2, kanye no-3, ngokulandelanayo. |
| I-CPD3610 | I-BLU-9931 | I-BLU9931 iyi-FGFR4 inhibitor enamandla, ekhethayo, nengenakuhlehliswa ene-IC50 ye-3 nM, cishe 297-, 184-, kanye nokukhetha okuphindwe ka-50 ngaphezulu kwe-FGFR1/2/3, ngokulandelana. |
