I-CPDD3721 | I-BEC HCl | I-BEC, eyaziwa nangokuthi i-S-(2-boronoethyl)-L-cysteine, iyisivimbeli esibopha kancane futhi esiqhudelanayo se-Arginase II esine-Ki ka-0.31 μM (ph 7.5). I-BEC ithuthukisa ngokuphawulekayo ukukhululeka okungancikile kwe-PEnile corpus canvernosum yemisipha ebushelelezi ku-vitro ekugxilweni okuphakathi kuka-0.1-1.0 mM. I-S-(2-boronoethyl) -L-cysteine ibophezela ku-arginase njenge-analogue yesimo soguquko futhi ithuthukise ukukhululeka kwemisipha ebushelelezi ku-penile corpus cavernosum yomuntu. |