I-AZD4547

Igama Lekhemikhali:

N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide

Ikhodi ye-SMILES:

O=C(NC1=NNC(CCC2=CC(OC)=CC(OC)=C2)=C1)C3=CC=C(N4C[C@H](C)N[C@H](C)C4 )C=C3

Ikhodi ye-InChi:

I-InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21( 29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8, 15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+

I-InChi Key:

I-VRQMAABPASPXMW-HDICACEKSA-N

Igama elingukhiye:

AZD4547, AZD-4547, AZD 4547, 1035270-39-3

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-AZD 4547 iyi-inhibitor ekhethiwe ye-fibroblast growth factor receptor (FGFR) i-tyrosine kinase enamanani e-IC50 angu-0.2, 2.5, kanye no-1.8 nM we-FGFR1, 2, kanye no-3, ngokulandelanayo.

Ithagethi: FGFR