FGF401

Igama Lekhemikhali:

N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4 -dihydro-1,8-naphthyridine-1 (2H) -carboxamide

Ikhodi ye-SMILES:

CN1CC(N(CC2=CC(CCCN3C(NC4=CC(NCCOC))=C(C#N)C=N4)=O)=C3N=C2C=O)CC1)=O

Ikhodi ye-InChi:

I-InChI=1S/C25H30N8O4/c1-31-7-8-32(23(35)15-31)14-18-10-17-4-3-6-33(24(17)29-21(18) 16-34)25(36)30-22-11-20(27-5-9-37-2)19(12-26)13-28-22/h10-11,13,16H,3-9, 14-15H2,1-2H3,(H2,27,28,30,36)

I-InChi Key:

BHKDKKZMPODMIQ-UHFFFAOYSA-N

Igama elingukhiye:

FGF401, FGF-401, FGF 401, 1708971-55-4

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-FGF-401 iyi-inhibitor ye-FGFR4 ekhishwe ku-patent WO2015059668A1, isibonelo esiyinhlanganisela 83; ine-IC50 ye-1.9 nM.

Ithagethi: FGFR4