I-TAS-120

Igama Lekhemikhali:

1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl] -2-propen-1-eyodwa

Ikhodi ye-SMILES:

C=CC(N1C[C@@H](N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C42)CC1)=O

Ikhodi ye-InChi:

I-InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28) 6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2 ,23,24,25)/t15-/m0/s1

I-InChi Key:

KEIPNCCJPRMIAX-HNNXBMFYSA-N

Igama elingukhiye:

I-TAS-120

Ukunyibilika: 

Isitoreji: 

Incazelo:

I-TAS-120 iyi-oral bioavailable inhibitor ye-fibroblast growth factor receptor (FGFR) enekhono lomsebenzi we-antineoplastic. I-FGFR inhibitor TAS-120 ibophezela ngokukhetha futhi ngokungenakuhlehliswa kokuthi ivimbele i-FGFR, okungase kuphumele ekuvinjweni kokubili kwendlela yokudlulisela isignali ephakathi kwe-FGFR kanye nokwanda kwamaseli e-tumor, kanye nokwanda kokufa kwamaseli kumaseli e-FGFR-expressing overexpressing tumor. I-FGFR iyi-receptor tyrosine kinase ebalulekile ekwandeni kweseli yesimila, ukuhlukaniswa nokuphila futhi ukubonakaliswa kwayo kulawulwa ezinhlotsheni eziningi zamaseli wesimila.

Ithagethi: FGFR