I-Derazantinib; I-ARQ-087

Igama Lekhemikhali:

(6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine

Ikhodi ye-SMILES:

COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1

Ikhodi ye-InChi:

I-InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24- 10-4-5-12-2 7(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H ,32,33,34)/t26-/m1/s1

I-InChi Key:

KPJDVVCDVBFRMU-AREMUKBSSA-N

Igama elingukhiye:

I-Derazantinib, ARQ-087, ARQ087, ARQ 087, 1234356-69-4

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-Derazantinib, eyaziwa nangokuthi i-ARQ-087, iyisivimbeli esitholakala ngomlomo se-fibroblast growth factor receptor (FGFR) esinomsebenzi we-antineoplastic ongaba khona. I-FGFR inhibitor ARQ 087 ibophezela futhi ivimbele ngamandla umsebenzi we-FGFR subtypes 1, 2 no-3. Lokhu kungase kuphumele ekuvinjweni kwezindlela zokudlulisela isignali eziqondiswe yi-FGFR, ukwanda kwe-tumor cell, i-tumor angiogenesis kanye nokufa kwe-tumor cell ku-FGFR-overexpressing tumor cell cell. . I-FGFR, i-receptor tyrosine kinase, ilawulwa ezinhlotsheni eziningi zamangqamuzana e-tumor futhi idlala indima ebalulekile ekwandeni kwamangqamuzana ethumba, ukuhlukaniswa, i-angiogenesis kanye nokuphila.

Ithagethi: FGFR