I-BLU-9931
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 100mg | Kukhona kusitoki | 220 |
| 300mg | Kukhona kusitoki | 500 |
| 1g | Kukhona kusitoki | 1350 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide
Ikhodi ye-SMILES:
C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O
Ikhodi ye-InChi:
I-InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10- 17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33 )(H,29,31,32)
I-InChi Key:
TXEBNKKOLVBTFK-UHFFFAOYSA-N
Igama elingukhiye:
BLU-9931, BLU9931, BLU 9931, 1538604-68-0
Ukunyibilika:I-Soluble ku-DMSO
Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).
Incazelo:
Kumaseli e-MDA-MB-453, i-BLU9931 ivimbela ngokunamandla i-phosphorylation yendlela yokusayina ye-FGFR4. I-BLU9931 ivimbela ukwanda kwemigqa yeseli ye-HCC eveza inkimbinkimbi yamasignali ye-FGFR4 eqinile, efana nemigqa yeseli ye-Hep 3B, HUH-7, ne-JHH-7, ene-EC50 ye<1 μM. I-BLU9931 iphinde ivimbele ukwanda kolayini beseli etholakala ku-PDX ngendlela eqinile yokusayina ye-FGFR4[1]. I-BLU9931 yenza ukuncipha kwesimila kumamodeli we-hepatocellular carcinoma aveza inkimbinkimbi ye-ligand/receptor esebenzayo ehlanganisa i-FGF19/FGFR4/KLB futhi yengeza kuhlu olukhulayo lwama-anti-FGFR4 ejenti[2].
Ithagethi: FGFR4
