I-Bardoxolone methyl

Igama Lekhemikhali:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4 ,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

Ikhodi ye-SMILES:

O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

Ikhodi ye-InChi:

I-InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H, 9-14,17H2,1-8H3/t20-,22?,24+,29+,30-,31-,32+/m1/s1

I-InChi Key:

WPTTVJLTNAWYAO-OROHISIGSA-N

Igama elingukhiye:

I-Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-synthetic oleanane triterpenoid CDDO (Into No. 81035) iyi-activator ye-Nrf2 evimbela ukwanda futhi ibangele ukuhlukaniswa kanye ne-apoptosis kumaseli omdlavuza ahlukahlukene. I-C-28 methyl ester ye-CDDO (CDDO methyl ester) ivimba ukuhlanganiswa kweselula kwe-inducible nitric oxide synthase (iNOS) kanye ne-inducible COX-2 kuma-macrophages egundane e-INF-γ-activated anenani le-IC50 elingu-0.11 nM. Idala i-apoptosis, yenza ukuhlukaniswa, futhi ivimbele impendulo yokuvuvukala kumaseli ahlukahlukene we-tumor ngokusebenzisa ukuvinjelwa kwe-IκBα kinase/NF-κB ukusayina. I-CDDO methyl ester inomsebenzi onamandla we-antidiabetic, inciphisa inkulumo ye-cytokine e-proinflammatory ku-fat high-feed-feed type 2 diabetic amagundane kanye namagundane e-Leprdb/db kanye nokuqalisa i-AMP-activated protein kinase kanye nokusebenza kwe-LKB1 emisipha nesibindi.

Ithagethi: NF-kB