I-BAY-1895344

Igama Lekhemikhali:

(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine

Ikhodi ye-SMILES:

CN1N=CC=C1C2=CC(N3[C@H](C)COCC3)=NC4=C(C5=CC=NN5)N=CC=C24.[H]Cl

Ikhodi ye-InChi:

I-InChI=1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6- 21-2 0(19(14)24-18)16-4-7-22-25-16;/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25);1H /t13-;/m1./s1

I-InChi Key:

KWQNBYGUBHMRPY-BTQNPOSSSA-N

Igama elingukhiye:

1876467-74-1;CAS:1876467-74-1;CAS:1876467-74-1;BAY-1895344, BAY1895344, BAY 1895344

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-BAY-1895344 iyi-ATR ekhethiwe (i-ataxia-telangiectasia ne-Rad3 ehlobene namaprotheni) inhibitor evimbela ukwanda kwe-spectrum ebanzi yemigqa yeseli yesimila somuntu (i-IC50 ephakathi = 78 nM). I-BAY-1895344 yenzelwe ukwelapha iziguli ezinamathumba aqinile athuthukile nama-lymphomas, futhi ibhekene nokuhlolwa komtholampilo kwesigaba I sokuphepha nokubekezelelana kweziguli ezinomdlavuza.

Ithagethi: ATR