I-LX-2761
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 100mg | Kukhona kusitoki | 500 |
| 500mg | Kukhona kusitoki | 800 |
| 1g | Kukhona kusitoki | 1200 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
N-(1-((2-(Dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R), 5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-butanamide
Ikhodi ye-SMILES:
O=C(NC(C)(C)C(NCCN(C)C)=O)CCCC1=CC=C(CC2=CC([C@H]3[C@H](O)[C@@ H](O)[C@H](O)[C@@H](SC)O3)=CC=C2C)C=C1
Ikhodi ye-InChi:
I-InChI=1S/C32H47N3O6S/c1-20-10-15-23(29-27(38)26(37)28(39)30(41-29)42-6)19-24(20)18-22- 13-11-21(12-14-22)8-7-9-25(36)34-32(2,3)31(40)33-16-17-35(4)5/h10-15, 19,26-30,37-39H,7-9,16-18H2,1-6H3,(H,33,40)(H,34,36)/t26-,27-,28+,29+,30 -/m1/s1
I-InChi Key:
I-BNPZTRDIESRGTC-IXYVTWBDSA-N
Igama elingukhiye:
LX-2761, LX2761, LX 2761, 1610954-97-6
Ukunyibilika:I-Soluble ku-DMSO
Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).
Incazelo:
I-LX2761 iyisivimbeli se-SGLT1 esisebenza endaweni esinamandla kakhulu ku-vitro futhi ibambezela ukumuncwa kwe-glucose emathunjini ku-vivo ukuze kuthuthukiswe ukulawulwa kwe-glycemic. I-LX2761 ine-hSGLt1 2.2 nM; hSGLT2 2.7 nM kanye F% =<2. I-LX2761 iyi-molecule enamandla kakhulu, ezinzile kumakhemikhali, futhi enomkhawulo wokukhanya ethole ubufakazi bomqondo ku-OGTT ngemithamo ephansi kakhulu. I-LX2761 yayiklanyelwe ukuthi ihlale emathunjini ngemva kokubeletha ngomlomo ukuze ivimbele i-SGLT1 endaweni ngaphandle kokuthikameze indlela ye-SGLT1/2 ezinso.
Ithagethi: SGLT1
