I-Osimertinib Mesylate

Igama Lekhemikhali:

N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino )phenyl)acrylamide mesylate

Ikhodi ye-SMILES:

CN(CCN(C)C)C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2 .OS(=O)(C)=O

Ikhodi ye-InChi:

I-InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3) 32-28-29-13-12-21(31-28 )20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2 -6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)

I-InChi Key:

FUKSNUHSJBTCFJ-UHFFFAOYSA-N

Igama elingukhiye:

AZD-9291, AZD9291, AZD 9291, Tagrisso,Osimertinib Mesylate, 1421373-66-1

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-Osimertinib, eyaziwa nangokuthi i-mereletinib kanye ne-AZD-9291, iyisivimbeli se-EGFR yesizukulwane sesithathu, ibonise isithembiso ezifundweni zangaphambi komtholampilo futhi inikeza ithemba ezigulini ezinomdlavuza wamaphaphu othuthukisiwe osekwazi ukumelana ne-EGFR inhibitors ekhona. I-AZD9291 isebenza kakhulu kumamodeli angaphambi komtholampilo futhi ibekezelelwa kahle kumamodeli ezilwane. Ivimbela kokubili ukuguqulwa kwe-EGFR esebenzayo nokungazweli ngenkathi isindisa uhlobo oluvamile lwe-EGFR olukhona kumaseli avamile esikhumba nasemathunjini, ngaleyo ndlela yehlise imiphumela engemihle ehlangabezwana nemithi etholakalayo njengamanje. I-Osimertinib yavunywa ngoNovemba 2015.

Ithagethi: EGFR