GSK2256098

Igama Lekhemikhali:

2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide

Ikhodi ye-SMILES:

CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C

Ikhodi ye-InChi:

I-InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22 -18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23) ,24)

I-InChi Key:

BVAHPPKGOOJSPU-UHFFFAOYSA-N

Igama elingukhiye:

GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-GSK2256098, eyaziwa nangokuthi i-GTPL7939, iyi-focal adhesion kinase-1 (FAK) inhibitor enemisebenzi engaba yi-antiangiogenic kanye ne-antineoplastic. I-FAK inhibitor GSK2256098 ivimbela i-FAK, engase ivimbele ukwenziwa kusebenze okuhlanganisiwe kwe-integrin kwezindlela ezimbalwa zokudlulisela isignali ezansi nomfula, okuhlanganisa i-ERK, JNK/MAPK ne-PI3K/Akt, ngaleyo ndlela ivimbele ukufuduka kweseli yesimila, ukwanda nokuphila, kanye ne-tumor angiogenesis. I-tyrosine kinase FAK ivamise ukwenziwa isebenze ngokubophezela kuma-interins ku-matrix engaphandle kweseli (ECM) kodwa ingase ilawuleke futhi yenziwe isebenze ezinhlotsheni zamaseli wesimila.

Ithagethi: FAK