I-CP-456773 sodium

Igama Lekhemikhali:

i-sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)(4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide

Ikhodi ye-SMILES:

O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]

Ikhodi ye-InChi:

I-InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15 -7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23 );/q;+1/p-1

I-InChi Key:

I-LFQQNXFKPNZRFT-UHFFFAOYSA-M

Igama elingukhiye:

MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 sodium usawoti, Cytokine release inhibitory drug 3, 2563373-9

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-CP-456773, eyaziwa nangokuthi i-MCC950 ne-CRID3, iyi-inhibitor enamandla futhi ekhethiwe ye-cytokine kanye ne-NLRP3 inflammasome inhibitor yokwelapha izifo ezivuthayo. I-CP-456773 ivimbela ukukhishwa kwe-interleukin 1β (IL-1β) kanye nokucubungula kwe-caspase 1. I-MCC950 ivimbe ukusebenzisa i-canonical kanye ne-noncanonical NLRP3 ekugxilweni kwe-nanomolar. I-MCC950 ivimbele ngokuqondile ukwenziwa kusebenze kwe-NLRP3 kodwa hhayi i-AIM2, NLRC4 noma i-NLRP1 inflammasomes. I-MCC950 inciphise ukukhiqizwa kwe-interleukin-1β (IL-1β) ku-vivo futhi yanciphisa ukuqina kokuhlolwa kwe-autoimmune encephalomyelitis (EAE), imodeli yesifo se-multiple sclerosis. I-MCC950 iyindlela yokwelapha engaba khona ye-syndromes ehambisana ne-NLRP3, ehlanganisa izifo ezizimele kanye ne-autoimmune, kanye nethuluzi lokucwaninga okuqhubekayo kwe-NLRP3 inflammasome empilweni yomuntu kanye nezifo.

Ithagethi: NLRP3