i-Nazartinib; I-EGF816; I-NVS-816

Igama Lekhemikhali:

(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)kodwa-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)- 2-methylisonicotinamide

Ikhodi ye-SMILES:

O=C(NC1=NC2=CC=CC(Cl)=C2N1[C@H]3CN(C(/C=C/CN(C)C)=O)CCCC3)C4=CC=NC(C)= C4

Ikhodi ye-InChi:

I-InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33( 26)20-8-4-5-15 -32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3 ,(H,29,30,35)/b11-7+/t20-/m1/s1

I-InChi Key:

IOMMMLWIABWRKL-WUTDNEBXSA-N

Igama elingukhiye:

I-Nazartinib ,EGF816, EGF-816, EGF 816, NVS-816, 1508250-71-2

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-Nazartinib, eyaziwa nangokuthi i-EGF816 kanye ne-NVS-816, iyisivimbeli esitholakala ngomlomo, esingenakuhlehliswa, sesizukulwane sesithathu, esikhethiwe se-epidermal growth factor receptor (EGFR) inhibitor, esinomsebenzi we-antineoplastic ongaba khona. I-EGF816 ibophezela ngokuhlanganyela futhi ivimbele umsebenzi wezinhlobo eziguqukayo ze-EGFR, okuhlanganisa i-T790M EGFR mutant, ngaleyo ndlela ivimbele ukusayinda okuphakathi kwe-EGFR. Lokhu kungase kubangele ukufa kweseli futhi kuvimbele ukukhula kwesimila kumaseli e-EGFR-overexpressing tumor cell. I-EGF816 ivimbela ngokukhethekile izinhlobo eziguquliwe ze-EGFR okuhlanganisa i-T790M, ukuguqulwa kokumelana okutholwe okwesibili, futhi ingase ibe nezinzuzo zokwelapha kumathumba anokumelana ne-T790M-mediated uma kuqhathaniswa namanye ama-EGFR tyrosine kinase inhibitors.

Ithagethi: EGFR