I-ARS-1630

Igama Lekhemikhali:

(R)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-zu-1-one

Ikhodi ye-SMILES:

"C=CC(N1CCN(C2=C3C=C(Cl)[C@@]([C@@]4=C(O)C=CC=C4F)=C(F)C3=NC=N2)CC1 )=O.[R]

Ikhodi ye-InChi:

I-InChi Key:

Igama elingukhiye:

I-ARS1630, ARS 1630, ARS-1630, 1698055-86-5

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-ARS-1630 iyi-atropisomer ye-R-conformational ye-ARS-1620, inamandla angaphansi ngokuphindwe ngo-1,000 kune-ARS-1620 (1.2 ± 0.6 M-1s-1) futhi ngaleyo ndlela isebenza njengenhlanganisela eyingqayizivele engasebenzi yokulawula.

Ithagethi: KRAS (K-Ras G12C)