I-IT-901
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 100mg | Kukhona kusitoki | 500 |
| 500mg | Kukhona kusitoki | 800 |
| 1g | Kukhona kusitoki | 1200 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H) -pyrimidinedione
Ikhodi ye-SMILES:
O=C(/C(C(N1)=O)=CC2=C3C=CC=CC3=C(OC)C=C2OC)NC1=S
Ikhodi ye-InChi:
I-InChI=1S/C17H14N2O4S/c1-22-13-8-14(23-2)11(9-5-3-4-6-10(9)13)7 -12-15(20)18-17(24)19-16(12)21/h3-8H,1-2H3,(H2,18,19,20,21,24)
I-InChi Key:
JHOPCCOYRKEHQU-UHFFFAOYSA-N
Igama elingukhiye:
IT-901, IT901, IT 901, 1584121-99-2
Ukunyibilika:I-Soluble ku-DMSO
Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).
Incazelo:
"I-IT-901 iyi-c-Rel Inhibitor Elamula Izakhiwo Ze-Anticancer Ku-Hematologic Malignancies Ngokuvimba I-NF-κB-Controlled Oxidative Stress Responses. I-IT-901 ivimbela ngokuqinile i-NF-κB subunit c-Rel. I-IT-901 icindezelwe i-graft-versus- isifo sokusingatha ngenkathi silondoloza umsebenzi we-graft-versus-lymphoma ngesikhathi se-allogeneic ukufakelwa kabusha. Ukuhlola okwengeziwe kwe-IT-901 yokwelashwa kwe-B-cell lymphoma yembula izakhiwo ze-antitumor ku-vitro kanye ne-vivo ngaphandle kokuvinjelwa ku-NF-κB-dependent lymphoma azange yenze amazinga akhulayo ezinhlobo ze-oxygen esebenzayo evamile i-leukocyte, ebonisa izakhiwo zayo zokukhetha umdlavuza i-IT-901 iyinhlangano yokwelapha enoveli yokwelapha izimila ze-lymphoid yabantu thuthukisa isifo sokuxhunyelelwa ngokumelene ne-host.
Ithagethi: NF-kB
