I-TH-302; Evofosfamide

Igama Lekhemikhali:

I-N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester

Ikhodi ye-SMILES:

O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C

Ikhodi ye-InChi:

I-InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)

I-InChi Key:

UGJWRPJDTDGERK-UHFFFAOYSA-N

Igama elingukhiye:

TH-302, TH302, TH 302, Evofosfamide, 918633-87-1

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-Evofosfamide, eyaziwa nangokuthi i-TH-302, i-hypoxia-activated prodrug ehlanganisa i-conjugate engu-2-nitroimidazole phosphoramidate enamandla okwenza umsebenzi we-antineoplastic. I-2-nitroimidazole moiety ye-hypoxia-activated prodrug TH-302 isebenza njenge-hypoxic trigger, ikhulula i-DNA-alkylating dibromo isophosphoramide mustard moiety ngaphakathi kwezifunda ezine-hypoxic zamathumba. Izicubu ze-Normoxic zingase zisindiswe ngenxa yomsebenzi othize we-hypoxia wale agent, okungenzeka unciphise ubuthi besistimu. Hlola izivivinyo zomtholampilo ezisebenzayo noma izivivinyo zomtholampilo ezivaliwe usebenzisa lesi sisebenzeli. (NCI).

Ithagethi: I-DNA Alkylating Agent