BLU-667

BLU-667
  • Orukọ:BLU-667
  • Katalogi No.CPD2049
  • CAS No.:2097132-94-8
  • Ìwọ̀n Molikula:532.27
  • Fọọmu Kemikali:C28H33FN8O2
  • Fun iwadi ijinle sayensi nikan, kii ṣe fun awọn alaisan.

    Alaye ọja

    ọja Tags

    Iwọn Pack Wiwa Iye owo (USD)

    Orukọ Kemikali:

    (1s, 4R) - N- ((S) -1- (4--fluoro-1H-pyrasol-1-yl) phenyl) -1-methoxy-4- (4-methyl-6-). (5-methyl-1H-pyrazol-3-yl) amino) pyrimidin-2-yl cyclohexane-1-carboxamide

    KỌỌDỌ SMILES:

    CC1=NC([C@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

    Koodu InChi:

    InChi=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27 (38)32-19 (3)20-5 -7-23 (8-6-20) 37-16-22 (29) 15-30-37/h5-8,13-16,19,21H,9-12H2,1-4H3,(H,32, 38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

    Bọtini InChi:

    HUQPYQIGHTXBNW-BDHWGLMFSA-N

    Koko-ọrọ:

    BLU-667; BLU 667; BLU667

    Solubility:DMSO

    Ibi ipamọ: 

    Apejuwe:

    BLU-667 jẹ oludaniloju ti o lagbara ati yiyan ti awọn iyipada RET, awọn idapọ, ati awọn alabọsi sooro asọtẹlẹ. Awọn idapọ RET jẹ awọn awakọ bọtini ti awọn aarun pupọ, pẹlu ẹdọfóró ati akàn tairodu, ati pe iwadii wa daba pe RET tun ṣe ipa pataki ninu diẹ ninu awọn aarun ọfin ati igbaya. Nipa ifọkansi ni igbakanna awakọ akọkọ ati awọn ẹda ti o sọ asọtẹlẹ ti o jẹ ki awọn sẹẹli alakan jẹ aibikita si itọju pẹlu awọn oogun ti a fọwọsi lọwọlọwọ,

    afojusun: RET


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