BAY-299

Orukọ Kemikali:

2- (2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl) -6- (3-hydroxypropyl) -1H-benz [de] isoquinoline-1,3 ( 2H) - dione

KỌỌDỌ SMILES:

OCCCC1=CC=C(C(N2C3=C(C)C=C(N(C)C(N4C)=O)C4=C3)=O)C5=C1C=CC=C5C2=O

Koodu InChi:

InChi=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8- 4-7-16-15 (6-5-11-29)9-10-18 (22(16)17)24(28)31/h4,7-10,12-13,29H,5-6, 11H2,1-3H3

Bọtini InChi:

OFWWWKWUCDUISA-UHFFFAOYSA-N

Koko-ọrọ:

BAY-299, BAY 299, BAY299, 2080306-23-4

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

BAY-299 jẹ onidalẹkun ti o lagbara ati yiyan ti bromodomain ati PHD ti o ni ika-ika (BRPF) amuaradagba ẹbi BRD1 (IC50 = 6 nM), ti a tun mọ ni BRPF2, ati bromodomain keji ti ifosiwewe ibẹrẹ transcription TFIID subunits 1 (TAF1; IC50). = 13 nM).1 BAY-299 je>30-agbo yan lori BRPF1, BRPF3, BRD9, ati ATAD2 ati pe o jẹ> 300-agbo yiyan lori BRD4.

afojusun: BRPF