GSK2256098

Orukọ Kemikali:

2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide

KỌỌDỌ SMILES:

CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C

Koodu InChi:

InChi=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22 -18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23 ,24)

Bọtini InChi:

BVAHPPKGOOJSPU-UHFFFAOYSA-N

Koko-ọrọ:

GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

GSK2256098, ti a tun mọ ni GTPL7939, jẹ adhesion kinase-1 (FAK) inhibitor pẹlu agbara antiangiogenic ati awọn iṣẹ antineoplastic. FAK inhibitor GSK2256098 ṣe idiwọ FAK, eyiti o le ṣe idiwọ imuṣiṣẹ integrin-mediated ti ọpọlọpọ awọn ipa ọna gbigbe ifihan agbara isalẹ, pẹlu ERK, JNK/MAPK ati PI3K/Akt, nitorinaa dẹkun ijira sẹẹli tumo, afikun ati iwalaaye, ati angiogenesis tumo. FAK tyrosine kinase ti wa ni deede muu ṣiṣẹ nipasẹ sisopọ si awọn integrins ninu matrix extracellular (ECM) ṣugbọn o le ṣe atunṣe ati mu ṣiṣẹ ni agbara ni ọpọlọpọ awọn iru sẹẹli tumo.

Àfojúsùn: FAK