Bardoxolone methyl

Orukọ Kemikali:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a, 9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

KỌỌDỌ SMILES:

O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

Koodu InChi:

InChi=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29 (5) 16-19 (18-33) 25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22 ?,24+,29+,30-,31-,32+/m1/s1

Bọtini InChi:

WPTTVJLTNAWYAO-OROHISIGSA-N

Koko-ọrọ:

Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)

Apejuwe:

Sintetiki oleanane triterpenoid CDDO (Nkan Nkan. 81035) jẹ Nrf2 activator ti o dẹkun afikun ati ki o fa iyatọ ati apoptosis ni orisirisi awọn sẹẹli alakan. C-28 methyl ester ti CDDO (CDDO methyl ester) ṣe idiwọ iṣelọpọ cellular ti inducible nitric oxide synthase (iNOS) ati COX-2 inducible ni awọn macrophages Asin ti INF-γ-ṣiṣẹ pẹlu iye IC50 ti 0.11 nM. O nfa apoptosis, ṣe iyatọ, o si ṣe idiwọ idahun iredodo ni orisirisi awọn sẹẹli tumo nipasẹ idinamọ ti IκBα kinase / NF-κB ifihan agbara. CDDO methyl ester ni iṣẹ-ṣiṣe antidiabetic ti o lagbara, idinku ikosile cytokine proinflammatory ni iru ounjẹ ti o jẹun ti o sanra pupọ ati ninu awọn eku Leprdb / db ati ti nfa amuaradagba amuṣiṣẹpọ AMP ati imuṣiṣẹ LKB1 ninu iṣan ati ẹdọ

Àfojúsùn: NF-kB