BAY-1895344

Orukọ Kemikali:

(R) -3-methyl-4- (4- (1-methyl-1H-pyrazol-5-yl)-8- (1H-pyrazol-5-yl) -1,7-naphthyridin-2-yl) morpholine

KỌỌDỌ SMILES:

CN1N=CC=C1C2=CC(N3[C@H](C)COCC3=NC4=C(C5=CC=NN5)N=CC=C24.[H]Cl

Koodu InChi:

InChI=1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6- 21-20 (19 (14)24-18)16-4-7-22-25-16;/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25) ;1H/t13-;/m1./s1

Bọtini InChi:

KWQNBYGUBHMRPY-BTQNPOSSSA-N

Koko-ọrọ:

1876467-74-1;CAS:1876467-74-1;CAS:1876467-74-1;BAY-1895344,BAY1895344,BAY 1895344

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

BAY-1895344 jẹ ATR ti o yan (ataxia-telangiectasia ati amuaradagba ti o ni ibatan Rad3) inhibitor ti o ṣe idiwọ itọsi titobi ti awọn laini sẹẹli tumo eniyan (agbedemeji IC50 = 78 nM). BAY-1895344 ti ni idagbasoke fun itọju awọn alaisan ti o ni awọn èèmọ to ti ni ilọsiwaju ati awọn lymphomas, ati pe o n gba idanwo ile-iwosan apakan I ti ailewu ati ifarada fun awọn alaisan alakan.

afojusun: ATR