LX-2761
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 100mg | O wa | 500 |
| 500mg | O wa | 800 |
| 1g | O wa | 1200 |
| Awọn iwọn diẹ sii | Gba Awọn asọye | Gba Awọn asọye |
Orukọ Kemikali:
N- (1- ((2- (Dimethylamino) ethyl) amino) -2-methyl-1-oxopropan-2-yl) -4- (2-methyl-5-(2S,3R,4R, 5S,6R) -3,4,5-trihydroxy-6- (methylthio) tetrahydro-2H-pyran-2-yl) benzyl) phenyl) -butanamide
KỌỌDỌ SMILES:
O=C(NC(C)(C)C(NCCN(C)C)=O)CCCC1=CC=C(CC2=CC([C@H]3[C@H](O)[C@@ H](O)[C@H](O)[C@@H](SC)O3=CC=C2C)C=C1
Koodu InChi:
InChi=1S/C32H47N3O6S/c1-20-10-15-23(29-27(38)26(37)28(39)30(41-29)42-6)19-24(20)18-22- 13-11-21 (12-14-22) 8-7-9-25 (36) 34-32 (2,3) 31 (40) 33-16-17-35 (4) 5 / h10-15, 19,26-30,37-39H,7-9,16-18H2,1-6H3,(H,33,40)(H,34,36)/t26-,27-,28+,29+,30 -/m1/s1
Bọtini InChi:
BNPZTRDIESRGTC-IXYVTWBDSA-N
Koko-ọrọ:
LX-2761, LX2761, LX 2761, 1610954-97-6
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).
Apejuwe:
LX2761 jẹ oludena SGLT1 ti agbegbe ti o ni agbara pupọ ninu vitro ati idaduro gbigba glukosi ifun ni vivo lati mu iṣakoso glycemic dara si. LX2761 ni hSGLt1 2.2 nM; hSGLT2 2.7 nM ati F% =<2. LX2761 jẹ alagbara pupọ, iduroṣinṣin kemikali, ati moleku ihamọ ihamọ itanna ti o ṣaṣeyọri ẹri imọran ni OGTT ni awọn iwọn kekere pupọ. LX2761 jẹ apẹrẹ lati wa ninu ifun lẹhin ifijiṣẹ ẹnu lati dena SGLT1 ni agbegbe laisi ni ipa lori ẹrọ SGLT1/2 ninu kidinrin.
afojusun: SGLT1
