Osimertinib Mesylate

Orukọ Kemikali:

N- (2- ((2- (dimethylamino) ethyl) (methyl) amino) -4-methoxy-5- ((4- (1-methyl-1H-indol-3-yl) pyrimidin-2-yl) amino )phenyl) acrylamide mesylate

KỌỌDỌ SMILES:

CN(CCN(C)C)C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2 .OS(=O)(C)=O

Koodu InChi:

InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3) 32-28-29-13-12-21 (31-28)20-18-35 (5)24-11-9-8-10-19 (20)24;1-5(2,3)4/ h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3, (H,2,3,4)

Bọtini InChi:

FUKSNUHSJBTCFJ-UHFFFAOYSA-N

Koko-ọrọ:

AZD-9291, AZD9291, AZD 9291, Tagrisso,Osimertinib Mesylate, 1421373-66-1

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)

Apejuwe:

Osimertinib, ti a tun mọ ni mereletinib ati AZD-9291, jẹ oludena EGFR iran-kẹta, ṣe afihan ileri ni awọn iwadii iṣaaju ati pese ireti fun awọn alaisan ti o ni awọn aarun ẹdọfóró to ti ni ilọsiwaju ti o ti di sooro si awọn inhibitors EGFR to wa tẹlẹ. AZD9291 n ṣiṣẹ gaan ni awọn awoṣe preclinical ati pe o farada daradara ni awọn awoṣe ẹranko. O ṣe idiwọ mejeeji ṣiṣẹ ati awọn iyipada EGFR sooro lakoko ti o tọju fọọmu deede ti EGFR ti o wa ninu awọ ara deede ati awọn sẹẹli ikun, nitorinaa idinku awọn ipa ẹgbẹ ti o pade pẹlu awọn oogun ti o wa lọwọlọwọ. Osimertinib ti fọwọsi ni Oṣu kọkanla.

afojusun: EGFR