THZ531
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 500 |
| 500mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4- (dimethylamino) kodwa-2-enamide
Ikhowudi yoncumo:
"O=C(NC1=CC=C(C(N2C[C@H](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C= C1)/C=C/CN(C)C "
Ikhowudi ye-InChi:
InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22(19-38)35-30-33-18-25(31)28(36- 30)24-17-32-26-9-4-3-8-23(24)26/h3-4,6,8-14,17-18,22,32H,5 ,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/t22-/m1/s1
Isitshixo se-InChi:
RUBYHLPRZRMTJO-MOVYNIQHSA-N
Igama elingundoqo:
THZ-531, THZ 531, THZ531, 1702809-17-3
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-THZ531 yi-CDK12 ehlangeneyo kunye ne-CDK13 covalent inhibitor. I-Cyclin-dependent kinases 12 kunye ne-13 (CDK12 kunye ne-CDK13) idlala indima ebalulekileyo ekulawuleni ukubhaliswa kofuzo. I-THZ531 ijolise ngokungenakujikwa kwi-cysteine ebekwe ngaphandle kwendawo ye-kinase. I-THZ531 ibangela ukulahlekelwa kwegama lofuzo kunye nokulahlekelwa okufanayo kunye ne-hyperphosphorylated RNA polymerase II. I-THZ531 inciphisa kakhulu ukubonakaliswa kwejene yempendulo yomonakalo we-DNA kunye nohlobo oluphambili lwe-super-enhancer-associated transcription factor. I-THZ531 ibangele ukufa kweeseli ze-apoptotic. Iimolekyuli ezincinci ezikwaziyo ukujolisa ngokuthe ngqo kwi-CDK12 kunye ne-CDK13 zinokunceda ke ngoko ukuchonga ii-subtypes zomhlaza ezixhomekeke ngakumbi kwimisebenzi yazo ye-kinase.
Ithagethi: CDK
