SEL120-34A

Igama:SEL120-34A

Inombolo yekhathalogu:CPD100910

Inombolo yeCAS:1609522-33-9 (isiseko sasimahla) 1609452-30-3 (HCl)

Ubunzima beMolekyuli:450.599

Ifomula yemichiza:C15 H19 Br2 Cl N4

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Igama leMchiza:

7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline Hydrochloride

Ikhowudi yoncumo:

CC1=C(Br)C(Br)=C2CCCN3C2=C1N=C3N4CCNCC4.[H]Cl

Ikhowudi ye-InChi:

InChI=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4- 18-5-8-20;/h18H,2-8H2,1H3;1H

Isitshixo se-InChi:

GQXLWUCQESKBSC-UHFFFAOYSA-N

Igama elingundoqo:

SEL120-34A; SEL 120-34A; I-SEL-120-34A; SEL12034A; SEL 12034A; I-SEL-12034A

Ukunyibilika:

Ugcino:

Inkcazo:

I-SEL120-34A yi-CDK8 inhibitor enamandla kwaye ekhethiweyo esebenzayo kwiiseli ze-AML ezinamazinga aphezulu e-serine phosphorylation ye-STAT1 kunye ne-STAT5 ye-transactivation domains. I-EL120-34A inqanda i-phosphorylation ye-STAT1 S727 kunye ne-STAT5 S726 kwiiseli zomhlaza kwi-vitro. Ngokuqhubekayo, ukulawulwa kwe-STATs- kunye ne-NUP98-HOXA9- exhomekeke kwi-transcript ibonwe njengendlela ebalaseleyo yesenzo kwi-vivo.

Ithagethi: CDK8

Ngaphambili: CPD100850

Okulandelayo: LDC000067