Rivicclib

Igama leMchiza:

I-2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride

Ikhowudi yoncumo:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

Ikhowudi ye-InChi:

InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28- 21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

Isitshixo se-InChi:

OOVTUOCTLAERQD-OJMBIDBESA-N

Igama elingundoqo:

P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

Ukunyibilika: 

Ugcino: 

Inkcazo:

I-Riviciclib, eyaziwa nangokuthi i-P276-00, i-flavone kunye ne-cyclin exhomekeke kwi-kinase (CDK) inhibitor enokuthi isebenze i-antineoplastic. I-P276-00 ibophelela ngokukhethekileyo kwaye inqanda i-Cdk4 / i-cyclin D1, i-Cdk1 / i-cyclin B kunye ne-Cdk9 / i-cyclin T1, i-serine / i-threonine kinases edlala indima ebalulekileyo ekulawuleni umjikelezo weseli kunye nokunyuka kwamaselula. Ukuvinjelwa kwezi kinases kukhokelela ekubanjweni komjikelo weeseli ngexesha lenguqu ye-G1/S, ngaloo ndlela ikhokelela ekungenweni kwe-apoptosis, kunye nokuthintela ukwanda kweeseli zethumba.

Ithagethi: CDK