I-Voruciclib

Igama leMchiza:

2-(2-Chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-1-benzopyran -4-enye

Ikhowudi yoncumo:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

Ikhowudi ye-InChi:

InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21( 19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

Isitshixo se-InChi:

MRPGRAKIAJJGMM-OCCSQVGLSA-N

Igama elingundoqo:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Ukunyibilika: 

Ugcino: 

Inkcazo:

I-Voruciclib, ekwabizwa ngokuba yi-P1446A-05, yiprotein kinase inhibitor ethe ngqo kwi-cyclin-dependent kinase 4 (CDK4) enomsebenzi we-antineoplastic. I-CDK4 inhibitor P1446A-05 inqanda ngokukodwa inguqu yesigaba se-CDK4-mediated G1-S, ukubamba i-cell cycling kunye nokuthintela ukukhula kweeseli zomhlaza. I-serine / threonine kinase CDK4 ifumaneka kwi-complex kunye ne-D-type G1 cyclins kwaye yi-kinase yokuqala ukuba isebenze ngokuvuselela i-mitogenic, ukukhulula iiseli ukusuka kwinqanaba elipholileyo ukuya kwinqanaba lokukhula kwebhayisikili ye-G1 / S; I-CDK-cyclin complexes iboniswe ukuba i-phosphorylate i-retinoblastoma (Rb) i-transcription factor in early G1, displaceing histone deacetylase (HDAC) kunye nokuthintela ukunyanzeliswa kwe-transcriptional.

Ithagethi: CDK4