| CPDB0099 | Quizartinib; AC-010220; AC-220 | I-Quizartinib iyi-inhibitor ye-FMS ehlobene ne-tyrosine kinase 3 (FLT3; Kd = 1.6 nM) kwaye ibonisa ukukhetha okuphezulu kwe-FLT3 xa ivavanywa kwiphaneli ye-227 kinases eyongezelelweyo. Ivimbela ukwanda kwe-leukemia ye-cell line ye-MV4-11, egcina i-homozygous FLT3-ITD ukuguqulwa, kunye nexabiso le-IC50 le-0.56 nM.1 Kwi-1 mg / kg / ngosuku, i-quizartinib ibonakaliswe ukwandisa ukusinda kwimouse. imodeli ye-FLT3-ITD acute myeloid leukemia kunye nokuphelisa amathumba kwi Imodeli ye-xenograft ye-FLT3 exhomekeke kwi-mouse kwi-10 mg / kg. |
