| CAT # | Igama lemveliso | Inkcazo |
| CPD100464 | Erdafitinib | I-Erdafitinib, eyaziwa ngokuba yi-JNJ-42756493, inamandla kwaye ikhetha i-bioavailable yomlomo, i-pan fibroblast growth factor receptor (FGFR) inhibitor enokuthi isebenze i-antineoplastic. Phezu kokulawulwa komlomo, i-JNJ-42756493 ibophelela kwaye inqanda i-FGFR, enokubangela ukuvinjelwa kweendlela ze-FGFR ezinxulumene ne-signal transduction pathways kwaye ngaloo ndlela ukuvinjelwa kwe-tumor cell proliferation kunye ne-tumor cell death kwi-FGFR-overexpressing cell tumor cells. I-FGFR, elawulwa kwiindidi ezininzi zeeseli zethumba, i-receptor tyrosine kinase iyimfuneko kwi-tumor cell proliferation, umahluko kunye nokusinda. |
| CPD3618 | TAS-120 | I-TAS-120 yi-oral bioavailable inhibitor ye-fibroblast growth factor receptor (FGFR) enomsebenzi onokuthi ube ne-antineoplastic. I-FGFR inhibitor TAS-120 ibophelela ngokukhethayo kwaye ingaguqukiyo kwaye inqanda i-FGFR, enokuthi ibangele ukuvinjelwa kokubini kwe-FGFR-mediated signal transduction pathway kunye ne-tumor cell proliferation, kunye nokwandisa ukufa kweeseli kwi-FGFR-overexpressing cell tumor cells. I-FGFR yi-receptor tyrosine kinase eyimfuneko kwi-tumor cell proliferation, ukwahlula kunye nokuphila kunye nokubonakaliswa kwayo kulawulwa kwiintlobo ezininzi zeeseli zethumba. |
| CPDB1093 | iDerazantinib; ARQ-087 | I-Derazantinib, eyaziwa ngokuba yi-ARQ-087, yi-inhibitor ye-bioavailable yomlomo ye-fibroblast growth factor receptor (FGFR) enomsebenzi we-antineoplastic. |
| CPDB0942 | I-BLU-554 | I-BLU-554 yi-fibroblast factor receptor 4 (FGFR4) inhibitor enokuthi ifumane unyango lwe-hepatocellular carcinoma kunye ne-cholangiocarcinoma. |
| CPD0999 | H3B-6527 | I-H3B-6527 (i-H3 Biomedicine) yi-inhibitor ekhethiweyo kakhulu ye-FGFR4 kunye nomsebenzi onamandla we-antitumour kwi-FGF19 imigca yeseli ekhulisiwe kunye neegundane. |
| CPD0997 | FGF401 | I-FGF-401 yi-inhibitor ye-FGFR4 ekhutshwe kwi-patent WO2015059668A1, umzekelo we-compound 83; ine-IC50 ye-1.9 nM. |
| CPDB0053 | I-AZD4547 | I-AZD 4547 yi-inhibitor ekhethiweyo ye-fibroblast growth factor receptor (FGFR) i-tyrosine kinase enemilinganiselo ye-IC50 ye-0.2, i-2.5, kunye ne-1.8 nM ye-FGFR1, i-2, kunye ne-3, ngokulandelanayo. |
| CPD3610 | I-BLU-9931 | I-BLU9931 yinto enamandla, ekhethiweyo, kunye ne-inhibitor ye-FGFR4 engenakuguqulwa kunye ne-IC50 ye-3 nM, malunga ne-297-, i-184-, kunye ne-50-fold selectivity phezu kwe-FGFR1 / 2 / 3, ngokulandelanayo. |
