THZ2

THZ2
  • Igama:THZ2
  • Inombolo yekhathalogu:CPDB1587
  • Inombolo yeCAS:1604810-84-5
  • Ubunzima beMolekyuli:566.06
  • Ifomula yemichiza:I-C31H28ClN7O2
  • Kuphando lwenzululwazi kuphela, hayi izigulane.

    Iinkcukacha zeMveliso

    Iithegi zeMveliso

    Ubungakanani bePakethi Ubukho Ixabiso (USD)
    100mg Ikhona evenkileni 500
    500mg Ikhona evenkileni 800
    1g Ikhona evenkileni 1200
    Iisayizi ezininzi Fumana iiQuotes Fumana iiQuotes

    Igama leMchiza:

    N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)kodwa-2- enoyl]amino]benzamide

    Ikhowudi yoncumo:

    O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN) (C)C)=O)=C5

    Ikhowudi ye-InChi:

    InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23(17-22)37-31-34-19-26 (32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H, 35,40)(H,36,41)(H,34,37,38)/b14-7+

    Isitshixo se-InChi:

    FONRCZUZCHXWBD-VGOFMYFVSA-N

    Igama elingundoqo:

    THZ-2, THZ 2, THZ2, 1604810-84-5

    Ukunyibilika:Inyibilika kwi-DMSO

    Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).

    Inkcazo:

    I-THZ2, i-analog ye-THZ1, enokukwazi ukunyanga umhlaza webele we-Triple-negative (TNBC), i-CDK7 inhibitor enamandla kwaye ekhethiweyo eyoyisa ukungazinzi kwe-THZ1 kwi-vivo. IC50: CDK7= 13.9 nM; Iiseli zeTNBC= 10 nM

    Ithagethi: CDK


  • Ngaphambili:
  • Okulandelayo:

  • Iimveliso ezinxulumeneyo

    Incoko ka-WhatsApp kwi-Intanethi!