MC180295
Iinkcukacha zeMveliso
Iithegi zeMveliso
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Igama leMchiza:
Rel-(4-amino-2-(((2S)-bicyclo[2.2.1]heptan-2-yl)amino)thiazol-5-yl)(2-nitrophenyl)methanone
Ikhowudi yoncumo:
O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O
Ikhowudi ye-InChi:
InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8- 9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10?,12-/m0/s1
Isitshixo se-InChi:
JRNXAQINDCOHGS-CBINBANVSA-N
Igama elingundoqo:
Ukunyibilika:
Ugcino:
Inkcazo:
I-MC180295 yi-CDK9 inhibitor ekhethiweyo kakhulu (IC50 = 5 nM). (I-MC180295 inomsebenzi obanzi wokuchasana nomhlaza kwi-vitro kwaye iyasebenza kwiimodeli zomhlaza we-vivo. Ukongeza, i-CDK9 inhibition ivakalisa i-immune checkpoint inhibitor α-PD-1 kwi-vivo, iyenza ibe yinjongo egqwesileyo yonyango lwe-epigenetic lomhlaza.
Ithagethi: CDK9
