Alvocidib

Igama leMchiza:

I-2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-enye

Ikhowudi yoncumo:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

Ikhowudi ye-InChi:

InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28- 21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12- ,17+/m1/s1

Isitshixo se-InChi:

BIIVYFLTOXDAOV-PXAZEXFGSA-N

Igama elingundoqo:

L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; I-Flavoperidol; Alvocidib

Ukunyibilika: 

Ugcino: 

Inkcazo:

I-Alvocidib yi-synthetic N-methylpiperidinyl chlorophenyl flavone compound. Njenge-inhibitor ye-cyclin-dependent kinase, i-alvocidib yenza ukuba kubanjwe umjikelezo weseli ngokuthintela i-phosphorylation ye-cyclin-dependent kinases (CDKs) kunye ne-down-regulating cyclin D1 kunye ne-D3 expression, okubangelwa ukubanjwa kwe-cell cycle ye-G1 kunye ne-apoptosis. Le arhente ikwayi-inhibitor ekhuphisanayo yomsebenzi we-adenosine triphosphate. Khangela izilingo zeklinikhi ezisebenzayo okanye izilingo zekliniki ezivaliweyo usebenzisa le arhente.

Ithagethi: CDK