BS-181

Igama:BS-181

Inombolo yekhathalogu:CPD100906

Inombolo yeCAS:1092443-52-1 (isiseko sasimahla) 1883548-83-1 (2HCl) 1397219-81-6 (HCl)

Ubunzima beMolekyuli:416.99

Ifomula yemichiza:I-C22H33ClN6

Kuphando lwenzululwazi kuphela, hayi izigulane.

Thumela i-imeyile kuthi Khuphela njengePDF

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ubungakanani bePakethi

Ubukho

Ixabiso (USD)

Igama leMchiza:

N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diamine hydrochloride

Ikhowudi yoncumo:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl

Ikhowudi ye-InChi:

InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22( 19)28)24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15 ,23H2,1-2H3,(H,24,27);1H

Isitshixo se-InChi:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Igama elingundoqo:

Ukunyibilika:

Ugcino:

Inkcazo:

I-BS-181 yi-CDK inhibitor ekhethiweyo kakhulu ye-CDK7 ene-IC (50) ye-21 nmol / L. Uvavanyo lwezinye ii-CDKs kunye nenye i-69 kinases ibonise ukuba i-BS-181 ivimbele i-CDK2 kuphela kwiindawo ezingaphantsi kwe-1 micromol / L, kunye ne-CDK2 ivinjelwe i-35-fold less potently (IC (50) 880 nmol / L) kune-CDK7. Kwiiseli ze-MCF-7, i-BS-181 inqande i-phosphorylation ye-CDK7 substrates, ikhuthaze ukubanjwa komjikelo weseli kunye ne-apoptosis ukuthintela ukukhula kwemigca yeseli yomhlaza, kwaye ibonise iziphumo ze-antitumor kwi-vivo.

Ithagethi: CDK7

Ngaphambili: Rivicclib

Okulandelayo: Alvocidib