LDC000067
Iinkcukacha zeMveliso
Iithegi zeMveliso
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Igama leMchiza:
3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide
Ikhowudi yoncumo:
O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O
Ikhowudi ye-InChi:
InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13( 9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)
Isitshixo se-InChi:
GGQCIOOSELPMBB-UHFFFAOYSA-N
Igama elingundoqo:
LDC000067; LDC-000067; LDC 000067
Ukunyibilika:
Ugcino:
Inkcazo:
I-LDC000067 yi-CDK9 inhibitor enamandla kwaye ekhethiweyo. I-LDC000067 inhibited in vitro transcription ngendlela ye-ATP-ekhuphisanayo kunye ne-dose-dependent. Ukuchazwa kweprofayili ye-Gene yeeseli eziphathwe nge-LDC000067 kubonise ukucuthwa okukhethiweyo kwee-mRNA ezihlala ixesha elifutshane, kubandakanywa nabalawuli ababalulekileyo bokwanda kunye ne-apoptosis. Uhlalutyo lwe-de novo RNA synthesis lucebise indima ebanzi eyahlukahlukeneyo ye-CDK9. Kwinqanaba lemolekyuli kunye neselula, i-LDC000067 iphinde yavelisa iziphumo ze-CDK9 inhibition ezifana nokuphuculwa kokunqumamisa kwe-RNA polymerase II kwiigenes kwaye, okona kubaluleke kakhulu, ukufakwa kwe-apoptosis kwiiseli zomhlaza. I-LDC000067 inqanda i-P-TEFb exhomekeke kwi-vitro transcription. Yenza i-apoptosis kwi-vitro kunye ne-vivo ngokudibanisa ne-BI 894999.
Ithagethi: CDK9
