I-CP-456773 sodium
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 500 |
| 500mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
isodiyam ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)(4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide
Ikhowudi yoncumo:
O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]
Ikhowudi ye-InChi:
InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3- 5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q; +1/p-1
Isitshixo se-InChi:
LFQQNXFKPNZRFT-UHFFFAOYSA-M
Igama elingundoqo:
I-MCC950, i-MCC 950, i-MCC-950, i-CP-45677, i-CP45677, i-CP 45677, i-CRID-3, i-CRID3, i-CRID 3, i-CP-456773 ityuwa yesodium, i-Cytokine release inhibitory drug 3, 256373-99
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-CP-456773, eyaziwa ngokuba yi-MCC950 kunye ne-CRID3, inamandla kwaye ikhetha i-cytokine release inhibitor kunye ne-NLRP3 inflammasome inhibitor yonyango lwezifo ezivuthayo. I-CP-456773 inqanda i-interleukin 1β (IL-1β) secretion kunye ne-caspase 1 processing. I-MCC950 ivalwe i-canonical kunye ne-noncanonical NLRP3 isebenze kwi-nanomolar concentrations. I-MCC950 inqanda ngokukodwa ukusebenza kwe-NLRP3 kodwa kungekhona i-AIM2, NLRC4 okanye i-NLRP1 inflammasomes. I-MCC950 yanciphisa ukuveliswa kwe-interleukin-1β (IL-1β) kwi-vivo kwaye yanciphisa ubunzima bovavanyo lwe-autoimmune encephalomyelitis (EAE), imodeli yesifo se-multiple sclerosis. I-MCC950 yindlela yonyango enokubakho kwi-syndromes ehambelana ne-NLRP3, kubandakanywa nezifo ezizimeleyo kunye nezifo ezizimele, kunye nesixhobo sokufunda ngakumbi i-NLRP3 inflammasome kwimpilo yabantu kunye nezifo.
Ithagethi: NLRP3
