NTN21277
Mahsulot detali
Mahsulot teglari
Paket hajmi | Mavjudligi | Narxi (AQSh dollari) |
Kimyoviy nomi:
(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-xloro-4-fluorofenil)amino)-7-metoksikinazolin-6-il) oksi)pentil)oksi)etoksi)propanamido)-3,3-dimetilbutanoil)-4-gidroksi-N-(4-(4-metiltiazol-5-il)benzil)pirolidin-2-karboksamid
SMILE kodi:
O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC )=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
InChi kodi:
InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-33(57) 26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8-17-64- 40-23-34-37(24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9- 14,21,23-24,27-28,33,38,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55, 58)(H,51,52,54)/t33-,38+,43-/m1/s1
InChi kaliti:
NICKHWYZMNLEPJ-TZSMONEZSA-N
Kalit so'z:
Gefitinib asosidagi PROTAC 3; NTN21277; NTN-21277; NTN 21277
Eruvchanligi:
Saqlash:
Tavsif:
NTN21277, shuningdek, Gefitinib asosidagi PROTAC 3 nomi bilan ham tanilgan, bu VHL-rekruting PROTAC bo'lib, EGFR va EGFR mutantlarining degradatsiyasini 11,7 nM DC50 va HCC827 xujayrasi (Exon 19 del) va (HCC825 xujayrasi) uchun 22,3 nM bilan qo'zg'atadi.
Maqsad: EGFR