NTN21277

Jina la Kemikali:

(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl)amino))-7-methoxyquinazolin-6-yl) oxy) pentyl) oksi) eth oxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Msimbo wa SMILES:

O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N =CN=C3C=C2OC)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C =C5

Msimbo wa InChi:

InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-3 3(57)26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8- 17-64-40-23-34-37 (24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9-14,21,23-24 ,27-28,33,3 8,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55,58)(H,51,52,54)/t33- ,38+,43-/m1/s1

Ufunguo wa InChi:

NICKHWYZMNLEPJ-TZSMONEZSA-N

Neno muhimu:

PROTAC 3 yenye makao yake Gefitinib; NTN21277; NTN-21277; NTN 21277

Umumunyifu: 

Hifadhi: 

Maelezo:

NTN21277, inayojulikana pia kama PROTAC 3 yenye makao yake Gefitinib ni PROTAC inayoajiri VHL ambayo husababisha uharibifu wa mabadiliko ya EGFR na EGFR yenye DC50 ya 11.7 nM na 22.3 nM kwa seli ya HCC827 (Exon 19 del) na seli H3258R (L8255R).

Lengo: EGFR