EAI-045

Jina la Kemikali:

2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

Msimbo wa SMILES:

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

Msimbo wa InChi:

InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8 -27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

Ufunguo wa InChi:

YTUFHOKUFOQRDF-UHFFFAOYSA-N

Neno muhimu:

EAI-045, EAI045, EAI 045, 1942114-09-1

Umumunyifu:Mumunyifu katika DMSO

Hifadhi:0 - 4°C kwa muda mfupi (siku hadi wiki), au -20°C kwa muda mrefu (miezi)

Maelezo:

EAI045 ia kizuia EGFR chenye nguvu na teule. EAI045 inalenga vibadilishi vya EGFR vinavyostahimili dawa lakini huhifadhi kipokezi cha aina-mwitu. EAI045 huzuia EGFR ya L858R/T790M-mutant yenye nguvu ya chini ya nanomolar katika majaribio ya biokemikali.

Lengo: EGFR