STING agonist-3

Ngaran Kimia:

(E)-1-(4-(5-carbamoyl-2-(1-étil-3-métil-1H-pirasol-5-karboxamido)-1H-benzo[d]imidazol-1-yl)tapi-2- en-1- yl) -2-(1-étil-3-métil-1H-pirazol-5-karboxamido) -7-(3-hidroksipropoksi) -1H-benzo[d]imidazole-5-karboxamide

Kode SMILES:

O=C(N)C1=CC=C(N(C(NC(C2=CC(C)=NN2CC)=O)=N3)C/C=C/CN4C5=C(N=C4NC(C6=CC) (C)=NN6CC)=O)C=C(C(N)=O)C=C5OCCCO)C3=C1

Kodeu InChi:

InChI=1S/C37H42N12O6/c1-5-48-28(16-21(3)44-48)34(53)42-36-40-25-18-23(3 2(38)51)10-11-27(25)46(36)12-7-8-13-47-31-26(19-24(33(39)52)20-30(31)55- 15-9-14-50)41-37(47)43-35(54)29-17-22(4)45-49(29)6-2/h7-8,10-11,16-20, 50 H,5-6,9,12-15H2,1-4H3,(H2,38,51)(H2,39,52)(H,40,42,53)(H,41,43,54)/b8 -7+

Konci InChi:

VHCDRDBBENBVEK-BQYQJAHWSA-N

kecap konci:

Kalarutan: 

Panyimpenan: 

Katerangan:

STING agonist-3, sasari tina patén WO2017175147A1 (conto 10), nyaéta agonist STING molekul leutik selektif sareng non-nukléotida kalayan pEC50 sareng pIC50 masing-masing 7.5 sareng 9.5. STING agonist-3 boga pangaruh anti tumor awét sarta poténsi tremendous pikeun ngaronjatkeun pengobatan kanker

Sasaran: STING