S-600918, Sivopixant

Ngaran Kimia:

(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 ,3,5-triazinan-1-yl]-2-métilpropanoat asam

Kode SMILES:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

Kode InChi:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-19-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H ,32,33)(H,28,29,34)/t16-/m0/s1

Konci InChi:

SKZQFKBIJUXXCG-INIZCTEOSA-N

kecap konci:

2414285-40-6; CAS: 2414285-40-6; CAS: 2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Kalarutan:Leyur dina DMSO

Panyimpenan:Garing, poék sareng dina 0 - 4 C kanggo jangka pondok (poé ka minggu) atanapi -20 C kanggo jangka panjang (bulan ka taun)

Katerangan:

Sivopixant, ogé katelah S-600918, nyaéta antagonis reséptor P2X3 selektif (P2X3 IC50, 4,2 nm; P2X2/3 IC50, 1100 nm). Sivopixant némbongkeun éfék analgesic kuat dina beurit sabagean modél ligation saraf sciatic (model Seltzer) tina allodynia (ED50, 0.4 mg / kg).

Target: antagonis reséptor P2X3 selektif