Quarfloxin

Ngaran Kimia:

5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl) étil)-3-oxo-6-((R)-3-(pirazin-2-yl)pyrrolidin-1-yl )-3H-benzo[b]pirido[3,2,1-kl]fenoksazin-2-karboxamide

Kode SMILES:

FC1=C(N2CC[C@@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC[ C@H]7N(C)CCC7)=O)C8=O)C8=C1

Kodeu InChi:

InChI=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42 -29-15-21-5-2-3-6-22(21)16-30(29)45-34-31(42)25(33(26)43)17-27 (36)32(34)41-14-9-23(19-41)28-18-37-11-12-38-28/h2-3,5-6,11-12 ,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H,39,44)/t23-,24+/m1/s1

Konci InChi:

WOQIDNWTQOYDLF-RPWUZVMVSA-N

kecap konci:

CX 3543; CX-3543; CX 3543; Quarfloxacin

Kalarutan: 

Panyimpenan: 

Katerangan:

Quarfloxin, ogé katelah Quarfloxacin sareng CX-3543, mangrupikeun turunan fluoroquinolone kalayan kagiatan antineoplastik. Quarfloxin ngaganggu interaksi antara protéin nukléolin sareng struktur DNA G-quadruplex dina template DNA ribosom (rDNA), interaksi kritis pikeun biogenesis rRNA anu overexpressed dina sél kanker; gangguan DNA G-quadruplex ieu: interaksi protéin dina biogenesis rRNA aberrant bisa ngakibatkeun inhibisi sintésis ribosom jeung apoptosis sél tumor.

Sasaran: