PCO371

Ngaran Kimia:

1-(3,5-dimétil-4-(2-((4-oxo-2-(4-(trifluoromethoxy)fenil))-1,3,8-triazaspiro[4.5]dec-1-en-8-yl )sulfonil)étil)fenil)-5,5-dimétilimidazolidin-2,4-dion

Kode SMILES:

O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C(OC(F)(F))F )C=C4)N5)C5=O)=O)C(C)=C2)=O

Kodeu InChi:

InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28(11-13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30, 31)32/h5-8,15-16H,9-14H2,1-4H3,(H,33,35,39)(H,34,38,40)

Konci InChi:

LDZJFVOUPUFOHX-UHFFFAOYSA-N

kecap konci:

PCO371; PCO-371; PCO 371

Kalarutan: 

Panyimpenan: 

Katerangan:

PCO371 mangrupikeun agonis PTHR1 anu kuat sareng selektif pikeun pengobatan hypoparathyroidism. Administrasi lisan tina PCO371 ka beurit osteopenic provokes kanaékan signifikan dina elehan tulang jeung nambahan kawates dina massa tulang. Dina beurit hypocalcemic, PCO371 mulangkeun kadar kalsium sérum tanpa ngaronjatkeun kalsium kemih, sarta kalawan épék kuat tur leuwih lila-langgeng ti suntik PTH.

Sasaran: PTHR 1