BMS-986165
Rincian produk
Tag produk
| Ukuran Pek | Kasadiaan | Harga (USD) |
| 10 mg | Aya sasayogian | 260 |
| 100 mg | Aya sasayogian | 530 |
| 1g | Aya sasayogian | 1350 |
Ngaran Kimia:
6-(cyclopropanecarboxamido)-4-((2-metoxy-3-(1-métil-1H-1,2,4-triazol-3-yl)fenil)amino)-N-(métil-d3)piridazin-3 -karboxamide
Kode SMILES:
O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2H]
Kodeu InChi:
InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)( H2,23,24,25,29)/i1D3
Konci InChi:
BZZKEPGENYLQSC-FIBGUPNXSA-N
kecap konci:
1609392-27-9；CAS:1609392-27-9；CAS:1609392-27-9；BMS-986165; BMS 986165; BMS986165; Deucravacitinib
Kalarutan:Leyur dina DMSO
Panyimpenan:Garing, poék sareng dina 0 - 4 C kanggo jangka pondok (poé ka minggu) atanapi -20 C kanggo jangka panjang (bulan ka taun).
Katerangan:
BMS-986165 mangrupikeun Inhibitor Allosteric Highly Potent sareng Selektif tina TYK2. BMS-986165 Blok Il-12, IL-23 sareng Tipe I Interferon Signaling sareng Nyadiakeun Efficacy Mantap dina Model Preclinical of Inflammatory Bowel Disease. MS-986165 potently ngiket kana domain Tyk2 pseudokinase (Ki = 0,02 nM), sarta pohara selektif ngalawan panel 265 kinase na pseudokinase. Sanyawa ieu potently ngahambat IL-23-, IL-12-, sarta Tipe I interferon-disetir signalling sélular jeung réspon transcriptional (IC50 rentang 2-14 nM).
Sasaran: TYK2
