GLPG0187
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 650 |
| 250mg | E teng thepeng e teng ka lebenkeleng | 960 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 1500 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
(S) -3-((2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl)pyrimidin-4- yl)amino) -2-((4-methoxyphenyl)sulfonamido)propanoic acid
SMILES Khouto:
O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC= C(OC)C=C5)=O
Khoutu ea InChi:
InChI=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23) 32-19(2)33-28(18)36-15-12-20(13-16-36)24-11-6-21-5-4-14-30-27(21)34-24/ h6-11,20,25,35H,4-5,12-17H2,1-3H3,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0 /s1
InChi Key:
CXHCNOMGODVIKB-VWLOTQADSA-N
Keyword:
GLPG0187, GLPG-0187, GLPG 0187, 1320346-97-1
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
Ka tekong e tiileng ea mohato, GLPG0187 e bonts'a khetho bakeng sa li-receptor tse ngata tsa RGD integrin tse nang le IC50s ea 1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM bakeng sa αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, le αvβ8, le αvβ8, le 1. GLPG0187 ke inhibitor e matla ea osteoclastic bone resorption le angiogenesis. Kalafo e nang le GLPG0187 e itšetlehileng ka tekanyo e eketsa tekanyo ea E-cadherin/vimentin, e leng ho etsang hore lisele li be le epithelial, sessile phenotype. GLPG0187 e itšetlehile ka tekanyo e fokotsa boholo ba aldehyde dehydrogenase e ngata ea lisele tsa mofetše oa prostate [1]. Kalafo ea GLPG0187 e fella ka ho potoloha ha lisele le ho bokellana. GLPG0187 e bonts'a phokotso e kholo e itšetlehileng ka tekanyo ea ho falla ha lisele tsa tumor. GLPG0187 maemong ohle e fokotsa haholo ho ata ha lisele[2].
Sepheo: αvβ1
