RGX-104 HCl

Lebitso la lik'hemik'hale:

(R) -2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid hydrochloride

SMILES Khouto:

O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 =CC=CC=C4)C)=C1.[H]Cl

Khoutu ea InChi:

InChI=1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31(33(28)35)34(36,37)38)23-30(26-11-4-2-5-12-26)27-13-6-3-7-14-27; /h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1

InChi Key:

LCMIYQOJZLRHTO-GJFSDDNBSA-N

Keyword:

RGX-104 HCl, RGX-104, RGX104, RGX 104, 610318-03-1

Sollubility:E qhibiliha ka DMSO

Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).

Tlhaloso:

RGX-104 ke sebete sa X receptor beta agonist e nang le mesebetsi e ka bang teng ea immunomodulating le antineoplastic. Holim'a tsamaiso ea molomo, RGX-104 e khetha ka mokhoa o ikhethileng, 'me e tlama ho LXRbeta, ka hona e kenya tšebetsong pontšo ea LXRbeta, e lebisang ho ngolisoeng ha liphatsa tsa lefutso tse itseng tsa tumor suppressor le ho theola taolo ea liphatsa tsa lefutso tse itseng tsa tumor. Sena se sebetsa ka ho khetheha polelo ea apolipoprotein E (ApoE), protheine e hatellang hlahala, liseleng tsa tumor le lisele tse ling tsa 'mele. Sena se kenya ts'ebetsong sesole sa 'mele sa tlhaho, se fella ka ho fokotseha ha lisele tsa immunosuppressive myeloid-derived suppressor (MDSCs), lisele tsa tumor le lisele tsa endothelial sebakeng sa tumor microenvironment. Sena se thibela ho phefumoloha ha 'mele oa ho itšireletsa mafung, ho matlafatsa likarabo tsa' mele oa ho itšireletsa mafung le ho thibela ho ata ha lisele tsa hlahala.

Sepheo: LXRbeta