FLT3

KATSE #	Lebitso la Sehlahiswa	Tlhaloso
CPDB0099	Quizartinib; AC-010220; AC-220	Quizartinib ke inhibitor ea tyrosine kinase 3 e amanang le FMS (FLT3; Kd = 1.6 nM) 'me e bontša khetho e phahameng bakeng sa FLT3 ha e lekoa khahlanong le sehlopha sa 227 kinases e eketsehileng. E thibela ho ata ha leukemia cell line ea motho MV4-11, e nang le phetoho ea homozygous FLT3-ITD, e nang le boleng ba IC50 ba 0.56 nM.1 Ho 1 mg/kg/letsatsi, quizartinib e bontšitsoe ho atolosa ho phela ho toeba. mohlala oa FLT3-ITD acute myeloid leukemia le ho felisa lihlahala ka har'a FLT3-e itšetlehileng ka mouse xenograft ea mohlala ho 10 mg/kg.