PQR530
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 500 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
(S) -4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine
SMILES Khouto:
NC1=NC=C(C2=NC(N3[C@H](C)COCC3)=NC(N4CCOCC4)=N2)C(C(F)F)=C1
Khoutu ea InChi:
InChI=1S/C18H23F2N7O2/c1-11-10-29-7-4-27(11)18-24-16(13-9-22-14(21)8-12(13)15(1 9)20)23-17(25-18)26-2-5-28-6-3-26/h8-9,11,15H,2-7,10H2,1H3,(H2,21,22)/ t11-/m0/s1
InChi Key:
SYKBZXMKAPICSO-NSHDSACASA-N
Keyword:
PQR530, PQR-530, PQR 530, 1927857-61-1
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
PQR530 ke inhibitor e matla haholo e habeli ea pan-PI3K/mTORC1/2. PQR530 inhibited protein kinase B (PKB, pSer473) le ribosomal protein S6 (pS6, pSer235/236) phosphorylation e nang le IC50 boleng ba 0.07 µM. PQR530 e bonts'itse khetho e ntle ka ho fetesisa ho phanele e pharalletseng ea kinase, hammoho le khetho e ntle haholo khahlano le li-enzyme tsa receptor tse sa amaneng le likanale tsa ion. Ho feta moo, PQR530 e bontšitse potency ka phanele ea lisele tsa kankere tsa 44 (NTRC Oncolines TM) ho thibela kankere ea lisele tsa kankere (boleng bo bolelang bakeng sa GI50 ea 426 nM). Ts'ebeliso ea molomo ea PQR530 ho litoeba e hlahisitse PK e leka-lekaneng ea lethal dose mme e bonts'a bioavailability e ntle ea molomo le ho kenella hantle ha boko.
Sepheo: PI3K/mTOR
