KATSE # | Lebitso la Sehlahiswa | Tlhaloso |
CPD100230 | JBJ-04-125-02 R-isomer | |
CPD3232 | NTN21277 | NTN21277, e tsejoang hape ka hore ke PROTAC 3 e thehiloeng ho Gefitinib ke VHL-recruiting PROTAC e bakang ho senyeha ha liphetoho tsa EGFR le EGFR ka DC50 ea 11.7 nM le 22.3 nM bakeng sa lisele tsa HCC827 (Exon 19 del) le H3255 cell (L8258). |
CPDB3615 | Nazartinib; EGF816; NVS-816 | Nazartinib, eo hape e tsejoang e le EGF816 le NVS-816, ke inhibitor e fumanehang ka molomo, e ke keng ea fetoloa, ea moloko oa boraro, e khethiloeng ke epidermal growth factor receptor (EGFR) inhibitor, e nang le ts'ebetso e ka bang teng ea antineoplastic. |
CPDB0934 | EAI-045 | EAI045 e matla le e khethang ea EGFR inhbitor. EAI045 e ikemiselitse ho khetha liphetoho tsa EGFR tse hananang le lithethefatsi empa e boloka moamoheli oa mofuta o hlaha. EAI045 e thibela EGFR ea L858R/T790M-mutant e nang le matla a tlase a nanomolar litekong tsa biochemical. |
CPDB0101 | Poziotinib | Mefuta e nang le poziotinib e ntse e etsoa lipatlisiso litekong tsa meriana bakeng sa phekolo ea EGFR-mutant lung adenocarcinoma. |
CPDB0137 | Osimertinib Mesylate | Osimertinib, eo hape e tsejoang e le mereletinib le AZD-9291, ke moloko oa boraro oa EGFR inhibitor, o bontšitse tšepiso lithutong tsa pele ho nako 'me o fana ka tšepo ho bakuli ba nang le kankere ea matšoafo e tsoetseng pele e seng e hanyetsana le li-inhibitors tsa EGFR tse teng. |